Search results for " ERK"
showing 10 items of 26 documents
Uncovering the Signaling Pathway behind Extracellular Guanine-Induced Activation of NO System: New Perspectives in Memory-Related Disorders
2018
Mounting evidence suggests that the guanine-based purines stand out as key player in cell metabolism and in several models of neurodegenerative disorders, such as Parkinson's and Alzheimer's diseases. Guanosine (GUO) and guanine (GUA) are extracellular signaling molecules derived from the breakdown of the correspondent nucleotide, GTP, and their intracellular and extracellular levels are regulated by the fine-tuned activity of two major enzymes, purine nucleoside phosphorylase (PNP) and guanine deaminase (GDA). Noteworthy, GUO and GUA, seem to play opposite roles in the modulation of cognitive functions, such as learning and memory. Indeed GUO, despite exerting neuroprotective, anti-apoptot…
The Role of ERK Signaling in Experimental Autoimmune Encephalomyelitis
2017
Extracellular signal-regulated kinase (ERK) signaling plays a crucial role in regulating immune cell function and has been implicated in autoimmune disorders. To date, all commercially available inhibitors of ERK target upstream components, such as mitogen-activated protein (MAP) kinase/ERK kinase (MEKs), but not ERK itself. Here, we directly inhibit nuclear ERK translocation by a novel pharmacological approach (Glu-Pro-Glu (EPE) peptide), leading to an increase in cytosolic ERK phosphorylation during T helper (Th)17 cell differentiation. This was accompanied by diminished secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF), a cytokine influencing the encephalitogenicity …
HSP60 activity on human bronchial epithelial cells
2017
HSP60 has been implicated in chronic inflammatory disease pathogenesis, including chronic obstructive pulmonary disease (COPD), but the mechanisms by which this chaperonin would act are poorly understood. A number of studies suggest a role for extracellular HSP60, since it can be secreted from cells and bind Toll-like receptors; however, the effects of this stimulation have never been extensively studied. We investigated the effects (pro- or anti-inflammatory) of HSP60 in human bronchial epithelial cells (16-HBE) alone and in comparison with oxidative, inflammatory, or bacterial challenges. 16-HBE cells were cultured for 1–4 h in the absence or presence of HSP60, H2O2, lipopolysaccharide (…
Katsaus Suomen varhaiseen atomihistoriaan
2022
Nykyisellä ydinteknologialla on lähinnä kaksi haaraa joita ovat ydinenergia ja lääketieteellinen isotooppitekniikka. Ensin mainitun lähtölaukauksena Suomessa pidetään nk. energiakomitean perustamista vuonna 1955. Tämän historian tutkimuksen painopiste on ollut 1960-ja 1970-luvun tapahtumissa, jotka liittyvät nykyisten ydinvoimalaitosten hankintakuvioihin. Professori Lennart Simons aloitti vakavasti otettavan ydinfysiikan tutkimuksen Suomessa ja oli alan ykkösnimi 1940- ja 1950-luvuilla kun koko länsimaailman yli pyyhkäisi atomiteknologian huuma, jota ehkä voi sanoa ensimmäiseksi teknologiahypeksi modernissa mielessä. Kirjan tarkoituksena on antaa lisävalaistusta suomalaisen ydinteknologian …
Role of adrenomedullin in the acute respiratory distress syndrome
Angiotensin II dependent cardiac remodeling in the eel Anguilla anguilla involves the NOS/NO system
2017
Angiotensin II (AngII), the principal effector of the Renin-Angiotensin System (RAS), plays an important role in controlling mammalian cardiac morpho-functional remodelling. In the eel Anguilla anguilla, one month administration of AngII improves cardiac performance and influences the expression and localization of molecules which regulate cell growth. To deeper investigate the morpho-functional chronic influences of AngII on the eel heart and the molecular mechanisms involved, freshwater eels (A. anguilla) were intraperitoneally injected for 2 months with AngII (1 nmol g BW-1). Then the isolated hearts were subjected to morphological and western blotting analyses, and nitrite measurements.…
Definitionen der ästhetischen Begriffe
1881
Datējums nav atrodams. Manuskripts, iespējams, attiecināms uz 19. gadsimta 80-jiem gadiem.
Erkki Kurenniemi : musiikin ja teknologian avantgardisti
2019
Erkki Kurenniemi (10.7.1941 – 1.5.2017) on kansainvälisesti tunnetuimpia suomalaisia musiikin avantgardisteja. Kuitenkin kesti kauan ennen kuin hänen arvonsa Suomessa tunnustettiin. Vasta 2000-luvulla häntä palkittiin ja hänen tuotantoaan ja toimintaansa alettiin laajemmin tutkia. Kurenniemen toimintakenttä taiteen alalla oli laaja käsittäen elektronisia soittimia ja sävellyksiä, elokuvia, mediataidetta ja tiedefantasioita. Kurenniemi oli koulutukseltaan fyysikko. Tässä artikkelissa luodaan yleiskatsaus Kurenniemen toimintaan ja saavutuksiin musiikin, taiteen ja teknologian aloilla, mutta perehdytään myös hänen teoreettisiin pohdiskeluihinsa, jotka ovat jääneet vähemmälle huomiolle. nonPeer…
Kansanperinteenkeruu ja muistitiedon keruuhanke : se oli täyttä työtä, melko rankkaa mutta antoisaa. Unohtumattomia kokemuksia --
2013
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: Rationale and importance to inhibiting these pathways in human health
2011
William H. Chappell 1 , Linda S. Steelman 1,2 , Jacquelyn M. Long 2 , Ruth C. Kempf 2 , Stephen L. Abrams 1 , Richard A. Franklin 1 , Jorg Basecke 3 , Franca Stivala 4 , Marco Donia 4 , Paolo Fagone 4 , Graziella Malaponte 4 , Maria C. Mazzarino 4 , Ferdinando Nicoletti 4 , Massimo Libra 4 , Danijela Maksimovic-Ivanic 5 , Sanja Mijatovic 5 , Giuseppe Montalto 6 , Melchiorre Cervello 7 , Piotr Laidler 8 , Michele Milella 9 , Agostino Tafuri 10 , Antonio Bonati 11 , Camilla Evangelisti 12 , Lucio Cocco 12 , Alberto M. Martelli 12,13 , and James A. McCubrey 1 1 Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University 2 Department of Physics, Greenville, N…